Abstract
The advancement of science and technology has successfully elucidated the distinct nature of cells, paving the way for single-cell omics. Since cells are the functional units of the human body, they make up all the existing systems in the body, so the intricacy of the human immune system is dictated by these very individual cells. The application of single-cell omics to the diverse field of immunology has equipped us to define novel subpopulations of immune cells and the role of existing and newly discovered cells in different maladies. It also bestows on us the power of profound profiling of immune cells, enabling us to take one step further towards understanding this highly complex system of the body, thereby providing us with the hope to fight the most dreadful disorders of the immune system, most especially autoimmunity. This chapter presents the fundamentals of single-cell omics as applied to immunology and discusses some specific applications to several of the most common autoimmune diseases.
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