Abstract
Chronic rhinosinusitis (CRS) can be differentiated into several phenotypes based on clinical criteria, using nasal endoscopy and computed tomography scanning; in contrast, endotyping of CRS aims to clarify the pathomechanisms, to provide information on the risk of disease progression or recurrence and on the possible use of innovative biologic treatment. Endotyping may best be structured around T-helper cells and their downstream events, such as tissue eosinophilia or neutrophilia; this approach involves the cytokines and chemokines related to specific T-helper cell populations and related markers such as IgE, ECP, and MPO. Endotyping is of specific interest for the development of new biologicals and prediction of the therapeutic response to them. Defining suitable biomarkers is, therefore, an urgent task.
Published Version
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