Abstract
Metastasis to bone is determined by both inherent characteristics of tumor cells and properties of bone niches. The bone-residing cells and bone-derived factors not only participate in maintaining dynamic bone homeostasis but also form specific niches, including premetastatic niche, perivascular niches, and stem cell niche for the seeding, survival, and outgrowth of disseminated tumor cells in bone. The main components in bone tissue that contribute to bone metastasis include hematopoietic stem cell (HSC)-osteoclast cell lineage, mesenchymal stem cell (MSC)-osteoblast cell lineage, and extracellular matrix and immune cells in bone marrow. Understanding of the complicated and dynamic nature of bone tissue and cancer cell–bone niche interactions may shed light into the mystery of metastatic dormancy, outgrowth, and progression, and facilitate the development of novel preventive or therapeutic strategies for bone metastasis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
