Abstract
Systems toxicology is the integration of classical toxicology approaches with quantitative analysis of large sets of molecular and functional changes occurring across multiple levels of biological organization. Systems toxicology–based research enables identification of the biological mechanisms and molecular pathways that are affected by exposure to cigarette smoke (CS) and, hence, provides a more comprehensive understanding of the causal link between exposure-induced molecular changes and the ensuing toxicity endpoints and adverse outcomes. This knowledge can then be used to quantify the biological effects of electronic nicotine delivery product aerosols relative to those of CS. This chapter provides a short description of the key methodologies used in systems toxicology.
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