Abstract
It has been well demonstrated that electronic nicotine delivery product (ENDP) aerosols contain significantly lower levels of known harmful and potentially harmful constituents (HPHCs) than cigarette smoke. However, these aerosols may contain other toxicologically relevant compounds that are specific to ENDPs, particularly electrically heated tobacco products (EHTPs). This chapter summarizes the application of advanced untargeted screening methodologies for comparative evaluation of EHTP aerosols versus cigarette smoke. When applying a reporting threshold (100 ng/item), the chemical constituents identified in the aerosol of the Tobacco Heating System 2.2 (THS) were also found in cigarette smoke, with an overall 10-fold reduction in the total number of constituents present compared with cigarette smoke. Untargeted differential screening revealed the presence of some compounds that were more abundant in THS aerosol. The potential toxicological effects of these compounds were considered to be outweighed by the substantial decrease in HPHCs in THS aerosol relative to cigarette smoke. Untargeted screening is not routinely applied for evaluation of e-vapor products and is not discussed in this chapter.
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