Abstract
SWI/SNF protein complex plays a crucial role in the regulation of eukaryotic gene expression. This large complex is required for transcriptional induction of a large number of yeast genes and is required for many transcriptional activators to enhance transcription. Although originally identified in the budding yeast, Saccharomyces cerevisiae, putative homologs for SWI/SNF subunits have been identified in Drosophila, mice, and humans. A current hypothesis is that the SWI/SNF complex facilitates activator function by contending with chromatin-mediated repression of transcription. This proposal is based on genetic studies in which chromatin components were identified as mutations that alleviated the requirement for the SWI/SNF complex in activator function. Recently, the yeast SWI/SNF complex has been purified to near homogeneity. The purified SWI/SNF complex antagonizes chromatin function—the complex uses the energy of ATP hydrolysis to stimulate the binding of an activator to nucleosomal DNA.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
