Abstract
Cone photoreceptors hold the most important role in the formation of central vision. Loss of cones results in severe visual impairment and a majority of retinal degenerative disorders are caused by or to the end of irreversible cone loss. Transplantation of photoreceptors from pluripotent stem cells (PSCs) has been demonstrated to restore the visual function of degenerated retinas preclinically. Here, we mainly summarize the protocols of generating cones from PSCs and overview the findings of clinical transplantation studies through PSCs-derived cones. Finally, we discuss the major challenges and future directions in cone photoreceptors regeneration and its clinical application for retinal degenerative diseases.
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