Abstract

One of the fundamental characteristics of regeneration is that the regenerating structure takes shape in association with an already existing remainder of the body. Reintegration entails the harmonious coupling of the regenerate with the body, and it can develop into a variety of forms. Reintegration can also begin near the termination of a regenerative process. This is particularly true for neural and sensory structures. Only after a regenerating motor nerve reaches its target muscle fiber, true structural and functional integration can be established. The classic case of skeletal tissue regeneration is the healing of a fracture of a long bone. Although at a microscopic level, there is considerable similarity in the healing of virtually all types of fractures, some reintegrative processes are most apparent in the healing of a nontreated displaced compound fracture. One of the fundamental reintegrative processes in bone regeneration is the remodeling of the regenerating bone to provide the best structural fit to the mechanical demands placed on the bone.

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