Abstract
Rapid Evaporative Ionization Mass Spectrometry (REIMS) allows the in vivo and in situ analysis and real-time identification of intact biological tissue. The combination of existing electrosurgical tools to mass spectrometry has permitted surgeons to take advantage of the rich chemical information contained within the surgical smoke that is traditionally discarded. These unique molecular signatures are modeled using multivariate statistics to create an identification algorithm for intraoperative margin assessment in cancer resections. The technique may also be modified for noninvasive endoscopic surgery. REIMS has additionally found application outside of surgery, in the identification of bacterial and fungal isolates to form the basis of a next-generation system for clinical microbiology and, in the differentiation of different food and agricultural commodities as fast and accurate tool to combat food fraud.
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