Abstract
In global public health, clinical treatment of pathogenic infection has become a grave issue. Antibiotics are now the only therapy option; however antibiotic overuse has resulted in resistance to multiple drugs and thereby a surge in fatality rates during antiinfection therapies. The advent of nano systems for various biological and drug delivery applications has piqued the interest of scientists all over the world. Microbes such as algae, fungi, bacteria, viruses, and yeast are known to be attracted to metals. The ability to develop microbially produced nanomaterials with greater resistance to hazardous metals has opened new possibilities. Metal-based nanoparticles are being used to deliver bioactive molecules and are known to have mechanisms of causing toxicity to bacteria that are nonspecific, making it harder for bacteria to acquire resistance while also broadening the antibacterial spectrum. Combination therapy using metal nanoparticles could be one of the options for combating current bacterial resistance to antibacterial drugs. While assessing safety in biomedical applications, it is critical to strike a compromise between antibacterial efficiency and metallic poisoning. This chapter focuses on nanosystems derived from metal-based nanoparticles and their corresponding antimicrobial activity.
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