Abstract
The introduction of deep brain stimulation for treatment-resistant disorders might very well lead to the most significant development in clinical psychiatry of the last 40 years—possibly offering a rise in hope for patients to whom medicine had hitherto little to offer. Furthermore, translational research on neuromodulation will allow us to glean something about the underlying cause of patients’ illnesses before figuring out a treatment that addresses the source of the problem. Major depression offers perhaps the best example of the rapid progress being made in understanding the biology of mental illness. We believe that focused, targeted treatment approaches that modulate specific networks in the brain will prove a more personalized, and thereby, effective approach to help treatment-resistant patients.
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