Abstract
This chapter reviews the current use of bioengineered skin with a focus on their clinical and preclinical applications. Skin tissue engineering must take into account the use of three key components: cells, scaffolds, and growth factors. Alternatives of these, depending upon the applicability, are discussed in this chapter. Skin bioengineering is nowadays a reality in clinical practice and different systems of skin equivalents have been successfully used to treat burn patients, chronic ulcers, epidermolysis bullosa patients, and other skin conditions. Bioengineered skin substitutes have been used in a preclinical context, not only to model diseases including genodermatosis, but also to better understand physiological processes. In the near future, the hope of skin tissue engineering is to become a multidisciplinary science where a next generation of biomimic skin substitutes can be developed.
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