Abstract
Access to the diverse heterocycles of unlimited potential was greatly realized by medicinal and organic chemists, crucial for drug design and development. Such molecules have immense applications in natural product synthesis, drug developments, and material science as semiconductors, organic conductors, light-emitting diodes, asymmetric organic catalysts, agrochemicals, and imaging agents. The creation of time-bound synthesis of such heterocycles economically requires a new approach for C–C and C-heteroatom bond formations. Synthesis of novel heterocycles with specific structural and substitution patterns which could satisfy the physicochemical requirements opens a new avenue for structure-based drug design. A minor change or modification in structural features such as placement of specific functional groups either electron-donating or attracting property, its size, hydrophobicity, lipophilicity, hydrogen bonding as well as inter and intramolecular weak interaction enhances the potency of selectivity, molecular stability, and other physicochemical properties.
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