Abstract
Eclosion hormone (EH) is a large, non-amidated neuropeptide containing six conserved cysteines. In insects it is produced by a small number of ventromedial neurosecretory cells in the brain. In moths, EH has clearly defined central and peripheral functions. Centrally released EH activates a specific network of peptidergic neurons (27/704) through elevation of cGMP. These neurons produce crustacean cardioactive peptide (CCAP), myoinhibitory peptides (MIPs), and bursicon that regulate the ecdysis and post-ecdysis processes. Peripherally released EH elicits cGMP production in endocrine Inka cells and causes massive ETH secretion to activate additional neurons required for ecdysis. EH probably participates in tracheal inflation and may act on the Verson’s glands during ecdysis.
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