Abstract
Supercritical fluid chromatography (SFC) has a long history, always on the cusp of greatness, but never achieving the same success as either gas chromatography or high-performance liquid chromatography. There have been several distractions that have prevented SFC from receiving a reasonable evaluation. By convention and by analogy with gas and liquid chromatography, it should describe a range of techniques in which the mobile phase is a supercritical fluid. However, many separations do not involve supercritical conditions and although this has no practical consequences, it has not helped with understanding of the method. It is currently in another phase of expansion and wider acceptance and certainly has many attractive features that should ensure its success outside niche markets and current application areas.
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