Abstract
Cancer immunotherapy has attracted considerable interest in recent years, though there are remaining translational problems, especially the off-target effect of immunotherapy, which causes unintended damage to normal tissues. Recent studies have shown that stimuli-responsive drug delivery systems have great potential for tumor site targeted delivery and spatiotemporal release of immunotherapeutics, based on the unique tumor microenvironment (e.g., acidic pH, reduced environment, overexpression of specific enzymes) or exogenous stimulation (e.g., light, magnetism and ultrasound). In this chapter, different categories of stimuli-responsive drug delivery systems and the specific design principles are carefully surveyed. Also, the current application of stimuli-responsive drug delivery systems in cancer immunotherapy is highlighted. Finally, the current challenges and opportunities of the clinical translation of stimuli-responsive drug delivery systems for cancer immunotherapy are concluded.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
