Abstract
Lipid–polymer hybrid nanoparticles (LPHNs) have been recently emerged as an effective drug delivery system with the combined advantages of liposomes and polymeric nanoparticles. The hybrid design incorporates the positive characteristics of lipids and polymers, which can synergistically overcome the limitations of traditional nanocarriers. This chapter focuses on the LPHN system with stimuli-responsive behavior for effective drug delivery, therapy, and diagnosis. We have described various types of LPHNs, along with their synthesis and composition. We have also discussed smart strategies based on endogenous (pH, redox, hypoxia, and reactive oxygen species) and exogenous (light, temperature, magnetic field, and ultrasound) stimuli in drug delivery applications. Finally, we have highlighted the challenges involved and future perspectives.
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