Chapter 7 - Cytotoxicity of nanoparticles toward diabetic cell models

Abstract

Cytotoxicity analysis is used to evaluate the toxicity of drug compounds toward the viability of cells in vivo. Nanoparticles can cause toxic effects on cells due to their small size and ease of cellular internalization. Nanotoxicology has become an area of interest that seeks to study the toxicity of nanoparticles toward humans and the environment. Cytotoxicity analysis of nanoparticles as a drug candidate can determine threshold concentrations essential to maximize therapeutic indices and minimize toxicity to cells. Thus it is critical to comprehensively evaluate the cytotoxicity of nanoparticles in drug formulations using diabetic cells and normal cells. The present chapter discusses the cytotoxicity of various nanoparticles, nanomedicines, and nanocomposites against diabetic cells. In addition, a potential cytotoxicity mechanism of nanoparticles toward diabetic cells is also discussed.