Abstract
The study aimed to find out a possible association of arsenic toxicity, HPV infection with OSCC, selecting population of West Bengal. After obtaining ethical clearance, 104 oral malignant, 103 oral premalignant cases and 200 controls were selected. On proper consent, their hair, buccal swab, peripheral venous blood samples were assessed for arsenic estimation by flow injection hydride generation atomic absorption spectrometry, HPV DNA detection by PCR and detection of chromosomal abnormalities by human leukocyte culture followed by Giemsa staining. A highly significant correlation of arsenic toxicity and HPV infection with oral carcinoma (p value = 2.18e-06, p value = 0.001, resp.) was observed, the effect of these two factors in this malignancy being (Phi coefficient = 0.2194839). Presence of chromosomal break was observed in ̴ 3% of oral malignant cases. The observations may indicate a possible associative role of arsenic toxicity with viral infection in context of this malignancy.
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