Abstract
Transdermal drug delivery system (TDDS) has an immense importance in the treatment of skin diseases and skin lesions because it reduces the adverse effects associated with systemic delivery. However, transdermal delivery is challenging due to the natural protective barrier of the skin that limits the permeation of drug molecules across the skin. Therefore, several strategies have been adopted to enhance the permeation of drugs and bioactive molecules through the skin. This chapter encompasses the advancement of engineered technologies in TDDS including sonophoresis, iontophoresis, electroporation, microneedle, nanoparticulate, and vesicular systems. In addition, these technologies in combination have been studied for synergistic effects and to enhance the physiochemical properties of drugs and the delivery carriers to treat various skin diseases (including acne, psoriasis, wounds, melanoma, etc.). These above-mentioned systems are overviewed in detail and they enlighten several methods to improve skin-related diseases.
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