Abstract
The efficient drug cargo to the heart and other relevant target sites is a key strategy for treatment of several cardiovascular disorders. Nanotechnology has got increased attention for delivering therapeutic agents and manifested an immense potential in the design of nanocarriers-based drug delivery systems. Heart-targeted nanocarriers-based drug delivery is an emerging, efficacious and effective strategy for treating a number of cardiac disorders including arrhythmias, atherosclerosis, thrombosis, myocardial infarction, ischemic heart diseases, and related complications. Nanocarriers-based delivery systems overcome the problems of severe side effects, nonspecificity, and normal cells’ damage that are associated with conventional approaches of delivering drugs. Moreover, the easy modification of physicochemical characteristics of nanocarriers, e.g., shape, size, and surface chemistry can greatly alter the in-vivo pharmacokinetics and pharmacodynamics of the encapsulated drugs that could provide better and improved treatment outcomes. Various drug delivery systems based on lipids, phospholipids, and polymers have been constructed for targeted delivery of drugs within the heart. The goal of this chapter is to provide an overview of the variety of nano-structures’ based carriers employed in delivering drugs for the successful treatment of a variety of cardiovascular ailments. Liposomes, dendrimers, polymer-drug conjugates, micelles lipid nanoparticles, nanostents, nanoburrs, microparticles, nanoparticles, and microbubbles are only a few of the many nanoscale drug delivery structures that have been discussed in detail.
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