Abstract
LC-MS is a powerful tool for toxicology applications in the clinical laboratory. The primary use of an LC-MS in a toxicology laboratory is for drug confirmation testing following an immunoassay screen and for broad spectrum drug screening. Multiple different LC-MS platforms including, LC-MS, LC-MS/MS, LC-TOF, LC-QTOF, and LC-Orbitrap have been used for toxicology testing. In addition, multiple different data acquisition modes have been described; including, targeted and untargeted data acquisition methods with and without data dependent acquisition of product ion spectra (DDA or DIA). This chapter highlights two LC-MS applications; including opioid confirmation testing and broad spectrum drug screening and one laboratory’s experience with method development, validation, and implementation. Several different approaches to both of these applications have been described in the literature, are referenced in this chapter, and can be used as resources for toxicology laboratories considering the implementation of LC-MS.
Published Version
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