Abstract
The delivery of nucleic acids (mostly small-interfering RNAs—siRNAs) shows promise when it comes to cancer treatment. siRNA is a hydrophilic polyanion that cannot readily cross the lipid bilayers of the cell membrane. The development of nanoparticle delivery systems for targeted drug delivery is discussed. Targeted delivery can be actively achieved by conjugating the therapeutic agent or carrier system to a tissue or cell-specific ligand or passively achieved by incorporating the therapeutic agent into a macromolecule or nanoparticle that passively reaches the target organ. siRNA blocks the expression of target genes in numerous cells. Apart from drug development and biological research siRNA possesses remarkable therapeutic properties. Polymeric micelle-mediated intracellular transport of siRNA may aid in overcoming the cellular barriers encountered by siRNA by facilitating cytoplasmic siRNA release, endosomal escape, and intracellular uptake. Successful siRNA delivery is the main challenge in understanding the utility and potential of siRNA.
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