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Abstract
The pharmaceutical industry is widely known for its discovery, development, and drug manufacture. The discovery of new, pharmacologically active principles has several challenges. Among these, the poor solubilization capacity of many available drugs is a major challenge of the pharmaceutical industry. This challenge was overcome by the introduction of drug nanocrystals in the field of drug development. In early days, the pharmaceutical industry considered these drug nanocrystals to be highly risky development candidates. However, changes in attitude and continuous research in this field have led to immense success. Drug nanocrystals have a major role in the emerging domain of pharmaceutical nanotechnology. A nanocrystal can be prepared from a hydrophobic compound coated with a thin hydrophilic layer. The biological reactions of the developed nanocrystals strongly depend on the chemical nature of the hydrophilic coating. Abundant nanocrystalline-based drug products are commercially available. Successful scientific research in this field can be seen in the number of patents on drug nanocrystals for various applications. These indicate that the pharmaceutical industry has embraced this universal approach to formulation, which is expected to advance further in the future. In this chapter, we focus on the development, application, and advantages of nanocrystal drugs.
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