Chapter 6 - Polymers Used in Peyer’s Patch Targeting

Abstract

Peyer’s Patches (PPs) consist of transmucosal clusters of lymphoid follicles overlaid with a specialized lymphoepithelium and play an essential role in the initiation of mucosal immune responses in the gut. Regardless of extensive achievements in the last few decades, for our understanding we will see in detail how PP are involved in the induction of immune responses. PPs also explicit types of dendrimers, which are present in the intestinal ileum and thereby in lumen that are polymeric molecules with three-dimensional networks. They are unique in their tree-like branched structure and have been explored as targeted drug delivery systems in the nanomedicine field in various disorders. Dendrimers are classified into various types including poly(amidoamine) dendrimers, poly(amidoamine-organosilicon) dendrimers, poly(propylene imine) dendrimers, tecto dendrimer, multilingual dendrimers, chiral dendrimers, etc. Dendrimers possess polyfunctional surfaces; therefore different types of drugs and pharmacokinetic modifiers can be attached. LIPOMER and different small-interfering RNA targeting have found profound use in research methodology.