Abstract
Malaria parasite Plasmodium falciparum is the most life-threatening species for humans. Over the past few years it has become extremely resistant to a wide range of antimalarial drugs. Thus, there is an urgent need to develop a new group of drugs by targeting a vital biomolecule in the parasite. Helicases are the most essential molecules in cell machinery. They act as motor proteins by converting chemical energy into mechanical energy and take part in all cellular functions, from DNA replication to translation. A new group of helicases, called Ded1 family, is a subfamily under the DEAD-box family of helicases, and participates in RNA metabolic activities. These helicases perform extensive functions in humans and yeast. Homologs of the Ded1 family have been reported in the P. falciparum. In this chapter, the in silico study of the few important members of the Ded1 family of helicases from P. falciparum—and their comparison with Homo sapiens—is presented.
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