Abstract
As helicases are a group of ubiquitous but distinct enzymes found in viruses, Bacteria, and eukaryotes, whose activity is essential in nucleic acid metabolism, they are emerging as important targets for novel antiviral, antibiotic and anticancer drugs. The most commonly used helicase assays are based on the displacement of single-stranded DNA or RNA in gel electrophoresis. Other sophisticated methods have been developed and are in use such as scintillation proximity assay, electrochemiluminescence assay, enzyme-linked immunosorbent assay, Förster resonance energy transfer, and a colorimetric method using DNA-functionalized gold-nanoparticles.
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