Abstract
In this chapter, we will focus on the aspects concerning quantitative analysis in forensic chemistry. Quantitation of traces of drugs, medicines, and metabolites in human biological samples is essential in the field of forensic toxicology, and therefore, this chapter focuses on forensic toxicological chemical analysis to illustrate this concept. Because of the complex biomatrices of the samples studied in forensic toxicology, the preferred analytical method is liquid chromatography coupled to mass spectrometry (LC-MS). The principles of bioanalysis with LC-MS will be discussed including the use of robust sample preparation and calibration procedures. Principles and features of various mass spectrometer instruments will be discussed. No matter how robust the method is, variation in the measured levels will always be observed. How the forensic toxicologist deals with this inherent measurement uncertainty in relation to absolute limits as stated in the law (i.e., the legal limit dilemma) will be explained in the final chapter.
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