Abstract
This chapter provides a comprehensive literature survey, based on more than 600 references, on application of differential scanning calorimetry (DSC) to study the solid-state properties of low molecular mass organic materials and pharmaceuticals. It presents the usefulness of DSC as a convenient, fast, and reliable tool for purity evaluation of active pharmaceutical ingredients. Then, it points to DSC as a primary method among thermal techniques for detection of various crystal forms, i.e., polymorphs, hydrates, and solvates, in a sample. It also confirms that DSC is a first-choice tool for investigation of compatibility between active pharmaceutical ingredients and excipients at the drug formulation technology. Additionally, this chapter discusses the usefulness of DSC to study the chemical kinetics, thermal behavior, and photostability as well as the thermal and thermooxidative degradation of organic materials and pharmaceuticals. At the end of the chapter, the relationships between the chemical structure and thermal degradation of organic materials and the mechanisms of thermal decomposition of active pharmaceutical ingredients are discussed.
Published Version
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