Abstract

The chapter discusses the needs, investigation, and importance of GaN biosensors for the early diagnosis of a wide variety of diseases to provide significant reductions in death rates as a result of timely treatment, which is a present-day challenge in many developed countries. The electrochemical biosensor systems on solution-gated AlGaN/GaN high electron mobility transistor structures convert biologic functions into electrical readings. A physics-based model for biosensors to predict the behavior of various diseases like breast cancer, detection of glucose level in human body, prostate cancer, kidney injury, and transplant rejection is also discussed. Due to their inherent characteristics such as chemically stable surface and bulk properties and the creation of high two-dimensional electron gas electron density at the heterointerface, these devices dominate over their silicon counterpart, which enables a detection of highly sensitive surface charges. These properties make GaN suitable for a biosensor platform for next-generation high-efficiency signal change biomaterials and point-of-care and disposable systems.

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