Abstract
No matter how well an animal, cellular or computation simulation model were developed; no model system can capture the full spectrum of clinical features and progression of human diseases. Therefore, the development of the best animal model possible with maximum potential to advance our knowledge on diseases such as Huntington's disease (HD) may better fit the mission. Transgenic HD monkeys that developed clinical features as the animals age are similar to those observed in human patients. Although HD monkeys hold great potential as a preclinical large animal model, HD monkey stem cells provide a unique platform for investigating the cellular pathogenesis and therapy discovery that is limited in HD monkeys. Here we present a fact check on the HD monkey model and HD monkey neural stem/progenitor cell model and their roles in advancing our knowledge in HD onset and development and their potential roles in future preclinical therapy development.
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