Abstract
Canine cognitive dysfunction (CCD) is a spontaneously occurring age-related neurodegenerative condition affecting dogs from 8years of age. The condition is characterized by progressive degenerative cerebral changes that are accompanied by cognitive decline. In companion dogs this is displayed clinically as distinct changes in behavior and daily routines. The clinical manifestation and neuropathological characteristics, such as the deposition of beta-amyloid protein, resemble those related to human Alzheimer's disease (AD). Predictive animal models are needed in translational research and drug development related to AD. Aged dogs are believed to represent a promising spontaneous animal model of human brain aging and early stage dementia of the Alzheimer's type. Aged companion dogs with CCD may complement the transgenic animal models that are primarily used in translational research today.
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