Abstract
This chapter discusses the major areas of preparative liquid chromatography (LC) application in pharmaceutical industry. New pharmaceutical products are found by chemical derivatization of known pharmaceuticals or by isolation of natural products. Both techniques need preparative liquid chromatography. For pharmaceutical compounds, found by synthesis of chemical derivatives, purity is advantageous. It is also governed by national laws. Therefore, synthesis of pure products plays a fundamental role in pharmaceutical industry. To attain this goal, side reactions and the structures of side-products should be known to optimize the synthesis. For structural identification the isolation of the unknown by-products is necessary. This is possible by expanding analytical LC to the preparative mg-scale. One of the areas of preparative column liquid chromatography is on the laboratory-scale, where lots to be separated lie between some mg and a few grams. In analytical preparative applications the chromatographs deliver flow velocities up to 5 cm sec –1 and have to work up to 300 bars.
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