Abstract
In multiple sclerosis (MS) there is a disturbed balance between overactivated inflammatory factors and inflammation-resolving and -inhibiting factors. The body can synthesize a series of lipid inflammation-resolving and -inhibiting endogenous autacoids to restore the balance. Autacoids are endogenous molecules that are produced on demand, and act directly in tissue where they are produced. There are a number of relevant families of these molecules: the N-acylethanolamides (NAEs) to which palmitoylethanolamide (PEA) belongs, the lipoxins, resolvins, protectins, and maresins. Omega-3 fatty acids are the precursors for the last three classes. The NAEs are formed from membrane phospholipids. There are no diet precursors known as of mid-2010s, but PEA itself is available as a food supplement and can be dosed easily and up to 2400mg/day; the compound has been evaluated in a number of randomized controlled trials, in a population over 5000 patients.1 Lipid autacoids might become an important new inroad in treating MS and its symptoms.
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