Abstract

The existence of enzymes able to catalyze pericyclic cycloadditions has been long debated. In the last years, thanks to outstanding developments achieved in chemical biology, it has been possible to study both from an experimental and theoretical point of view, the mechanisms underlying putative natural pericyclic reactions. Although evidence seems to suggest that there are enzymes selected by evolution to catalyze pericyclic cycloadditions, many questions are still pending. Answers will enable the preparation of tailor-made enzymes able to catalyze the formation of targeted compounds or explore new sectors of the chemical space.

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