Chapter 4 - Enantioselective Fluorination

Abstract

Organofluorine compounds have been widely applied in medicinal chemistry. Therefore, new methods for preparing chiral fluorinated molecules while controlling their stereochemistry are highly required. Although enantioselective construction of fluorinated chiral carbon center is still a challenging synthetic operation, the study on enantioselective fluorination has been steadily progressing for the past two decades. This chapter focuses on recent advances in the catalytic method of enantioselective fluorination utilizing organocatalysts, Lewis acid, and transition metal catalysts. Several examples of their applications to the synthesis of biologically relevant molecules are also introduced.