Abstract

Concerns for animal well-being and competitive livestock industries underlie the requirement for drug and nutrient delivery systems for ruminants that protect active ingredients from ruminal fermentation. In addition to delivering drugs or nutrients directly to the small intestine for absorption, commercially viable delivery systems must meet safety, and cost criteria. Compared with products developed for human use, cost constraints have impeded the development of effective post-ruminal delivery systems and rumenstable products. This chapter outlines both the physiological and technical considerations encountered in the design of effective post-ruminal delivery systems. It discusses the formulation strategy for a pH-dependent rumen-stable coating system and methods for in vitro and in vivo evaluation of post-ruminal delivery systems. It also discusses the ruminant digestive system and the digestive system of a simple-stomached animal and the difference between these two.

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