Abstract
Amino acid production operates at the million-tonne scale and is currently based on glucose derived from starch, or on fructose- and sucrose-containing molasses. The substrate spectrum of Corynebacterium glutamicum, the workhorse of amino acid production, has recently been broadened by metabolic engineering to allow access to pentose sugars present in lignocellulosic hydrolyzates. Unlike most microorganisms, C. glutamicum is able to simultaneously utilize pentoses and hexoses sugars present in, for example, rice straw or wheat bran hydrolyzates. The potential of C. glutamicum as a safe and efficient platform organism for biotechnological production has been demonstrated not only for amino acid production but also, by metabolic engineering, for production of other high-volume products. Future research will address the transfer of amino acid production based on hydrolyzates of rice straw and similar agro-wastes from the laboratory scale to the technical scale.
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