Abstract
This chapter investigates the evidence available to support the use of MGN-3/BioBran® as an adjuvant to the existing immunotherapeutic modalities and anticancer drugs. Many immunotherapeutic agents, such as interleukin-2 (IL-2), and chemotherapeutic drugs are toxic. Increased efficacy while lowering doses of the aforementioned modalities would offer better options for patients. MGN-3/BioBran is an enzymatically modified arabinoxylan rice bran that has the ability to activate different arms of the immune system, such as natural killer (NK) and dendritic cells (DC); increase the proliferation of T and B cells; and enhance the production of several cytokines. In addition, data have shown that human NK cells treated with MGN-3/BioBran in the presence of IL-2 demonstrate higher activity than with either treatment alone. Studies have also showed that MGN-3/BioBran exhibits a synergistic effect on cancer cell apoptosis when combined with anticancer drugs such as daunorubicin and adriamycin, as well as other natural anticancer agents such as curcumin, caffeine, and baker's yeast. Results suggest that MGN-3/BioBran could be used as an adjuvant to the existing immunotherapeutic and anticancer modalities.
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