Abstract
The calcitonin (CT)/calcitonin gene-related peptide (CGRP) family belongs to a multigenic family including amylin (AMY) and adrenomedullin (AM). Common structural features of the family include a conserved intramolecular ring consisting of six or seven aa residues, and an amide group at the C-terminus. The presence of CT-like peptides in invertebrates has been reported. Therefore, the ancestral molecule of the CT/CGRP peptide family may have appeared before the divergence of protostomes and deuterostomes. The receptors are divided into two subtypes: the calcitonin receptor (CTR), which binds CT, and the calcitonin-like receptor (CLR), for which the endogenous ligand is unknown. CGRP, AMY, AM1, AM2, and AM5 are distinguished by the coexpression of CTR or CLR with receptor activity modifying proteins. CT has a hypocalcemic activity. AMY plays a physiological role in glucose regulation. AM and CGRP are regulators of vascular tone and cardiovascular development.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
