Abstract
Despite great advances in pathogenesis of airway diseases, research on airway diseases continues to present several challenges. Traditional classification of diseases based on symptoms, signs, and syndromes may not be sufficient. The concept of precision medicine has emerged to address some of these challenges, from diagnostic and therapeutic points of view. The present chapter summarizes current knowledge on chronic obstructive pulmonary disease (COPD) phenotyping, from different perspectives. Disease heterogeneity is analyzed, along with initiatives to unravel different clinical expressions, and variability of underlying mechanisms, as well as relationship with therapeutic response. Modern COPD phenotyping should overcome the limitations of clinical medicine, with high-throughput technology and bioinformatics as its pillars.
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