Abstract
Ventricular-arterial coupling (VAC) plays an important role in the pathophysiology of heart disease. VAC assessment has independent diagnostic and prognostic value in various clinical conditions, such as hypertension, diabetes, and inflammatory diseases, and may be used to improve risk stratification of patients. Furthermore, systemic arterial compliance and valvulo-arterial impedance in valvular heart disease possess a significant diagnostic and prognostic value and may monitor the effects of therapeutic interventions on vascular and cardiac function. Treatment with favorable effects on VAC may delay the onset of heart failure and presumably improve prognosis in heart failure. In this chapter, we describe the clinical implications of VAC in cardiac diseases and heart failure. Additionally, we focus on therapeutic interventions that appear to improve VAC and thereby modify prognosis.
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