Abstract
Body temperature regulation is indispensable for the survival of homeothermic animals. To achieve robust thermoregulating function even in fluctuating ambient temperature, homeothermic animals detect peripheral and core brain temperature. The hypothalamic thermoregulating center integrates temperature information from the periphery and the brain to drive adequate thermoregulating outputs to maintain body temperature through the autonomic nervous system. Thermoregulation is achieved by regulating the total balance between thermogenesis and heat dissipation. Transient receptor potential (TRP) channels, especially those having temperature sensitivity, are known to be involved in temperature sensation in peripheral sensory neurons, the hypothalamic thermoregulating center, and in effector tissues that are involved in thermogenesis and heat dissipation. This chapter reviews currently known functions of TRP channels in thermoregulation, aspects of TRP function in thermoregulation that are currently unclear, and the potential of TRP channels as therapeutic targets.
Published Version
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