Abstract
This chapter conducted some experiments to test the biocompatibility of the mineralized collagen (MC). In such experiments, the effect of MC material and bone marrow mesenchymal stem cells (MSCs) cultured on the cell phenotype confirmed that MC is a good tissue scaffold material, easily complexed with MSC, suitable for seed cell attachment, growth, proliferation, and differentiation, and has no effect on the cell phenotype. In terms of genetic toxicity of MC and its effect on cultured cells in vitro, it can be seen from this experiment that nanohydroxyapatite composite collagen material has no potential genotoxicity and no inhibitory effect on periodontal ligament fibroblasts, osteoblast proliferation, and differentiation. The experimental evaluation of the osteoclasts of MC promoted osteoblast differentiation and function through regulating a network of osteogenic factors. The MC material has passed the biocompatibility safety assessment.
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