Abstract
From gestation through menopause in women, and andropause in men, fluctuations in luteinizing hormone (LH) release contribute to the development and maintenance of the reproductive system. Of note, increasing evidence also supports extra-gonadal roles for LH within the central nervous system (CNS), particularly as it relates to cognition and plasticity in aging and age-related degenerative diseases such as Alzheimer disease (AD). However, despite increasing reports in the past decade that solidify the role of this hormone in these processes, relating LH function and dysfunction to neuronal function and behavior, the mechanisms underlying LH action within the brain and how they influence cognition and plasticity loss remain poorly understood; in fact they are often in conflict. This chapter aims to provide an up-to-date review of the literature addressing the role of LH signaling in the context of CNS aging and disease. Additionally, we also aim to provide insight from the perspective of LH receptor (LHCGR) signaling and trafficking upon ligand binding that may unify currently conflicting theories regarding the role of LHCGR signaling in CNS function and dysfunction in aging and disease.
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