Abstract
Aging is associated with numerous biological mechanisms and cellular responses mediated by several molecular pathways. Aging plays a decisive role in cognitive impairment and in the architectural transformations that occur in the brain. Furthermore, the management of demented patients involves numerous economic and human resources, and it is a hot topic of the field of the research. In 1998, Patrick “Pat” O’Reilly Brown developed microarray technology for genome-wide analysis. This method is based on the uses of microchips containing anchored arrays of 1000 short DNA probes for the large-scale interrogation of gene expression. In recent years, this technology has found several applications and functions; in particular, it was used in the field of medicine and related areas. One of the areas of application is represented by neuroscience. However, the microarray study based on brain biopsies presents different technical problems such as the postmortem interval time on brain tissue preservation, the complete collection of clinical data, and the correct choice of available array platforms. The use of microarray technology in neuroscience represents a valid strategy to follow in order to obtain new responses to the mechanisms that regulate the processes underlying aging and its related pathology.
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