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Abstract
This chapter focuses on the OK blood group system. The history, terminology, expression, database accession numbers, and the carrier molecule related to the OK blood group system are reviewed. The function and disease association of the OK blood group system is also discussed. CD147 is the human homolog of rat OX-47 antigen, mouse basigin, and chicken neurothelin. Human CD147 (EMMPRIN–extracellular matrix metalloproteinase inducer) on tumor cells binds an unknown ligand on fibroblasts, which stimulates their production of collagenase and other extracellular matrix metalloproteinases, thus enhancing tumor cell invasion and metastases. The monocarboxylate (lactate) transporters, MCT1 and MCT4, require CD147 for their correct plasma membrane expression and function.
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