Abstract
This chapter discusses the Colton blood group system. The terminology, expression, database accession numbers, and the carrier molecule related to the Colton blood group system are also reviewed. This blood group was named in 1967 for the first of the three original producers of anti-Coa. In red blood cells (RBCs), channel-forming integral protein (CHIP)-1 exists as a dimer and accounts for 2.4% of the total membrane protein. The function and disease association of the Colton blood group system is discussed. Aquaporin (AQP) 1 accounts for 80% of water re-absorption in kidneys and is a determinant of vascular permeability in the lung. Monosomy 7, weak expression associated with certain chromosome 7 rearrangements, and leukemia are some of the diseases associated with this blood group system. The chapter discusses the terminology, occurrence, antithetical antigen, and expression of various antigens like Coa, Cob and Co3.
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