Abstract
Lipophilicity is one of the most studied physicochemical properties. Methods for lipophilicity have been in use for many years. An extensive set of published lipophilicity values for drugs and other compounds has been compiled by Hansch et al. [1]. Reliable and inexpensive in silico lipophilicity tools are commonly used in drug discovery. Lipophilicity can be measured in high-throughput format using microtiter partitioning-, high-performance liquid chromatography-, or capillary electrophoresis-based methods. In-depth methods for lipophilicity include octanol/buffer equilibrium shake flask partitioning and pH metric titration. Lipophilicity values are usually measured for drug candidates to support structure-activity relationships, absorption and tissue distribution prediction, physiologically based pharmacokinetic modeling, preformulation, formulation, and environmental assessment.
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