Abstract
Small intestinal motility disorders may be either primary (neuropathic or myopathic, that may be inherited or sporadic) or secondary to several systemic illnesses and drugs. Small intestinal motility disorders may remain asymptomatic or present with trivial symptoms mimicking “functional” gastrointestinal disorders or with an obvious intestinal pseudo-obstruction syndrome. Clinical evaluation and investigations should be directed towards assessing the severity, extent, etiology, inheritance, nutrition, complications, extra-gastrointestinal involvement and the associated conditions. Investigations to evaluate small intestinal motility disorders include abdominal radiograph, barium small bowel series, computerized tomography, gastrointestinal transit studies, antroduodenal manometry, histology of full-thickness small intestinal biopsy, and investigations directed to detect involvement of other organs, etiology, complications, and nutritional status. Treatment for small intestinal motility disorders depend on etiology, severity, and extent of involvement and include nutritional support, prokinetics, rifaximin for small intestinal bacterial overgrowth, small intestinal transplantation for advanced stage of the disease. Small intestinal electrical stimulation for motility disorders is currently under development.
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